Copper-Catalyzed Multi-Component Reactions: Synthesis of - download pdf or read online

By Yusuke Ohta

A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles through catalytic domino response together with multi-component coupling used to be built, and is the 1st instance of a three-component indole formation with no generating salts as a byproduct. in response to this response, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was once entire which represents an remarkable isoquinoline synthesis via a four-component coupling response. Following those effects, broad program reviews utilizing one-pot palladium-, acid-, or base-promoted cyclization published that indole- or isoquinoline-fused polycyclic compounds will be with ease synthesized via multi-component reactions. because the thought of eco-friendly Chemistry turns into ever extra very important, those findings may supply effective and atom-economical techniques to the diversity-oriented synthesis of bioactive compounds containing a fancy constitution. this is able to result in improvement of promising drug leads with structural complexity. The paintings of this thesis will cross directly to encourage the bogus examine of many readers.

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Copper-Catalyzed Multi-Component Reactions: Synthesis of Nitrogen-Containing Polycyclic Compounds (Springer Theses) by Yusuke Ohta


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