By Lazaros C. Triarhou
This booklet is the fruits of fifteen years of study at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterized
by means of genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the single on hand laboratory version with a prolonged ailment that mimics Parkinson's sickness. Structural and useful elements of
intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical points of donor mobile survival, ultrastructural findings on
synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor similar molecules, degrees of striatal amino acid receptors, and behavioural results of
unilateral and bilateral neuronal transplantations.
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Additional info for Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease (Advances in Experimental Medicine and Biology)
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Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson’s Disease (Advances in Experimental Medicine and Biology) by Lazaros C. Triarhou
by Brian
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