By Hong-Yang Chuang
This thesis specializes in the synthesis and vaccine assessment of the prostate tumor- linked carbohydrate antigen RM2. the writer first offers using the [1+2+3] one-pot sequential technique to effectively synthesise the RM2 antigen and its analogues as unmarried stereoisomers in each glycosylation step, generating strong yields and stereoselectivity. He then introduces the conjugation of the unreal RM2 antigen to the service protein CRM197 in a regular variety of 1–10 to create the prostate melanoma vaccine candidate, that's mixed with α-galactosylceramide C1, its analogue C34, or Alu. the result of the vaccination reviews in mice also are defined and point out that the most powerful anti-RM2 antigen titer is exhibited whilst one molecule of diphtheria toxin (DT) is conjugated with a typical of 4.7 molecules of RM2 antigen (DT-RM4.7) and adjuvanted with the glycolipid C34. extra importantly, the prompted mouse antibodies mediate the powerful complement-dependent cytotoxicity (CDC) opposed to the prostate melanoma telephone line LNCap. The learn awarded during this thesis is the 1st ever to effectively synthesize this complicated glycan molecule. due to the steric challenge of the adjoining sialyl moiety, the advent of 2 sialic acid devices to the compact and inflexible 3,4 di branched galactoside unit is particularly difficult and the β-selective and effective glycosylation of the galactosamine moiety on the 4-position of di branched galactose can also be problematic.
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Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer (Springer Theses) by Hong-Yang Chuang
by Charles
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